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Assessment of Inflammation in 3D Reconstructed Human Skin Exposed to Combined Exposure to Ultraviolet and Wi-Fi Radiation

TitleAssessment of Inflammation in 3D Reconstructed Human Skin Exposed to Combined Exposure to Ultraviolet and Wi-Fi Radiation
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2023
AuthorsSzilágyi, Z., Németh Z., Bakos J., Kubinyi G., Necz P.P., Szabó E., Thuróczy G., Pinto Rosanna, and Selmaoui B.
JournalInternational journal of molecular sciences
Volume24
ISSN14220067
Abstract

In the human environment, the increasing exposure to radiofrequency (RF) radiation, especially that emitted by wireless devices, could be absorbed in the body. Recently, mobile and emerging wireless technologies (UMTS, DECT, LTE, and Wi-Fi) have been using higher frequencies than 2G GSM systems (900/1800 MHz), which means that most of the circulating RF currents are absorbed into the skin and the superficial soft tissue. The harmful genotoxic, cytotoxic, and mutagenic effects of solar ultraviolet (UV) radiation on the skin are well-known. This study aimed at investigating whether 2422 MHz (Wi-Fi) RF exposure combined with UV radiation in different sequences has any effect on the inflammation process in the skin. In vitro experiments examined the inflammation process by cytokines (IL-1α, IL-6, IL-8) and MMP-1 enzyme secretion in a 3D full-thickness human skin model. In the first study, UV exposure was immediately followed by RF exposure to measure the potential additive effects, while in the second study, the possible protective phenomenon (i.e., adaptive response) was investigated when adaptive RF exposure was challenged by UV radiation. Our results suggest that 2422 MHz Wi-Fi exposure slightly, not significantly increased cytokine concentrations of the prior UV exposure. We could not detect the adaptive response phenomenon.

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85147894454&doi=10.3390%2fijms24032853&partnerID=40&md5=7e17fe3c6f074242f52e4c94ac40c145
DOI10.3390/ijms24032853
Citation KeySzilágyi2023