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Oxidative Stress Status in Post Stroke Patients: Sex Differences

TitoloOxidative Stress Status in Post Stroke Patients: Sex Differences
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione2022
AutoriSiotto, M., Germanotta M., Santoro Massimo, Canali R., Pascali S., Insalaco S., Cipollini V., Papadopoulou D., Antonacci E., and Aprile I.
RivistaHealthcare (Switzerland)
Volume10
ISSN22279032
Abstract

After a cerebral stroke insult, there is an overproduction of Reactive Oxygen Species (ROS), which overcome the antioxidant defenses, causing further tissues damage. The status of oxidative stress in stroke patients over time, particularly in those undergoing rehabilitation treatments, has been poorly investigated. We analyzed the oxidative stress status in 61 subacute stroke patients (33 females and 28 males) admitted to our rehabilitation center by measuring, in serum: hydroper-oxides levels (d-ROMs), antioxidant activity (BAP test), and the relative antioxidant capacity (OSI index). We also analyzed patients for glucose levels and lipid profile. In addition, we analyzed the correlation between oxidative stress status biomarkers and motor deficits, disability, and pain. Almost all patients showed high or very high levels of d-ROMs, while BAP levels were apparently in the reference range of normality. Females had lower BAP values (females: 2478 ± 379; males: 2765 ± 590; p = 0.034) and lower OSI index (females: 5.7 ± 1.9; males: 6.8 ± 1.9; p = 0.043). Moreover, in the male group, the correlation with motor impairment and disability showed a worsened motor performance when oxidative stress is higher. Female group, on the other hand, had an unexpected different trend of correlation, probably due to an unbalanced systemic oxidative stress. Further research is needed to see if sex differences in oxidative stress status in subacute stroke patients persist after rehabilitation. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85130211978&doi=10.3390%2fhealthcare10050869&partnerID=40&md5=e2bf875236eccb2ed395236a441ed1d7
DOI10.3390/healthcare10050869
Citation KeySiotto2022