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High-intensity static magnetic field exposure devices for in vitro experiments on biopharmaceutical plant factories in aerospace environments

TitoloHigh-intensity static magnetic field exposure devices for in vitro experiments on biopharmaceutical plant factories in aerospace environments
Tipo di pubblicazionePresentazione a Congresso
Anno di Pubblicazione2015
AutoriLopresto, Vanni, Merla Caterina, Pinto Rosanna, and Benvenuto Eugenio
Conference NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
EditoreInstitute of Electrical and Electronics Engineers Inc.
ISBN Number9781424492718
Abstract

Three high-intensity static magnetic field (SMF) exposure devices have been designed and realized for application to in vitro experimental research on hairy root cultures, supposed to grow in extreme environments- as those of space aircrafts- for producing biopharmaceutical molecules. The devices allow the exposure at two different levels of induction magnetic (B) field (250 mT and 500 mT) plus sham for blind exposure. The exposure levels can be considered representative of possible B-fields experienced within the habitat of a spacecraft in presence of active magnetic shielding systems. Each device can house a single 85-mm diameter Petri dish. Numerical simulations have been performed to accurately evaluate the B-field distribution in the biological target. Numerical results have been confirmed by measured data, proving that designed setups allows exposure to SMFs with a homogeneity better than 90%. The exposure devices will be employed for experiments scheduled within BIOxTREME research project, funded by the Italian Space Agency (ASI). © 2015 IEEE.

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84953288992&doi=10.1109%2fEMBC.2015.7318506&partnerID=40&md5=33c188b777815d735bb181b88a042b5f
DOI10.1109/EMBC.2015.7318506
Citation KeyLopresto2015893