| Title | Fabrication and characterization of poly(lactic acid)/poly(ε-caprolactone) blend electrospun fibers loaded with amoxicillin for tunable delivering |
|---|---|
| Publication Type | Articolo su Rivista peer-reviewed |
| Year of Publication | 2015 |
| Authors | Valarezo, E., Tammaro Loredana, Malagón O., González S., Armijos C., and Vittoria V. |
| Journal | Journal of Nanoscience and Nanotechnology |
| Volume | 15 |
| Pagination | 4706-4712 |
| ISSN | 15334880 |
| Keywords | Amoxicillin, Caprolactone, chemistry, drug carrier, Drug Carriers, electrochemical analysis, Electrochemical Techniques, Electrospinning, Electrospun fibers, Fabrication and characterizations, Lactic acid, nanofiber, Nanofibers, nanotechnology, Poly (epsiloncaprolactone), Poly lactic acid, polycaprolactone, polyester, Polyesters, polylactic acid, polymer, Polymers, procedures, Processing parameters, Spinning (fibers), Textile blends, Thermal behaviours |
| Abstract | Blends of poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL), loaded with different amounts of Amoxicillin antibiotic (AMOX) were electrospun to investigate their release properties and obtain a controlled and tuneable release. The processing parameters for electrospinning were set up and reliable membranes were obtained. Morphology and thermal behaviour were found dependent on the component ratio as well as on the incorporated drug amount. A very different release kinetics of the two pristine polymers, very rapid for PCL and very slow for PLA, reflected in intermediate release time. However comparing the release amount with that predicted by the mixture rule a preferential incorporation of AMOX into PLA can be inferred. Copyright © 2015 American Scientific Publishers All rights reserved. |
| Notes | cited By 4 |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84920849203&doi=10.1166%2fjnn.2015.9726&partnerID=40&md5=c303ced69bdd9d65feb31254b0054a6a |
| DOI | 10.1166/jnn.2015.9726 |
| Citation Key | Valarezo20154706 |
