Sorry, you need to enable JavaScript to visit this website.

The Frequency Dependent Response of Sinewave Electropermeabilization

TitleThe Frequency Dependent Response of Sinewave Electropermeabilization
Publication TypePresentazione a Congresso
Year of Publication2020
AuthorsGarcia-Sanchez, T., De Angelis A., Apollonio F., Liberti M., Mir L.M., and Merla Caterina
Conference Name2020 IEEE MTT-S International Microwave Biomedical Conference, IMBioC 2020
KeywordsCell membranes, cytology, Different frequency, Electric fields, Electrical modeling, Electropermeabilization, electroporation, Frequency dependence, Frequency dependent, Narrowband signal, Theoretical framework, Wide frequency bands
Abstract

The permeabilization of biological membranes by electric fields, known as electroporation and electropermeabilization, has been traditionally performed using square electric pulses. These signals distribute the energy in a wide frequency band. In this paper, authors investigate the use of sine waves, which are narrow band signals, to provoke electropermeabilization and the frequency dependence of this phenomenon. Single bursts of sine waves at different frequencies in the range from 8 kHz-130 kHz were applied to DC-3F cells. Electroporation was studied in the plasma membrane and the internal organelles membrane using calcium as a permeabilization marker. Additionally, a double-shell electrical model was simulated to give a theoretical framework to our results. © 2020 IEEE.

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85104407766&doi=10.1109%2fIMBIoC47321.2020.9385025&partnerID=40&md5=49c1b9d7819163279b69a282c2c4c538
DOI10.1109/IMBIoC47321.2020.9385025
Citation KeyGarcia-Sanchez2020