Radiation therapy for cancer, used in approximately 50% of patients, must be balanced against the risk of radiation-induced injury at the target area and surrounding regions. The skin is one of the most common areas for injury, due to inflammatory and fibrotic response, so that skin tolerance is often the limiting factor in radiotherapy. Therefore, the identification in mouse models of relevant genes modulating genetic susceptibility to radiotherapy-associated skin fibrosis may point to pathways of importance for assessment of individual response and prognosis and could advance personalization of radiation dose parameters