A catastrophic event like a radiological/nuclear (R/N) emergency may potentially involve hundreds or thousands of people. The management of such a large number would quickly overwhelm the medical facilities in charge preventing the subjects exposed to the higher doses receive adequate medical treatment. The established biodosimetry approach such as dicentric or micronuclei count provide results respectively after 50h or 75 h, a very long time for the emergencies’ management. With the aim of validating a new tool of different biomarkers for measuring the absorbed radiation dose soon after exposure in order to split exposed subjects depending on dose, together with Prof Noha Awad, HIPH University of Alessandria (ET) we are carrying out the ongoing research program “A Panel of Biomarkers as Novel Tool for Early Detection of Radiation Exposure” funded by NATO SPS. The panel include biomarkers of genetic damage (Comet assay, H2AX, micronuclei), oxidative stress and inflammation (i.e. FlT3, IL6, citrulline, amylase, C reactive protein …).. Biomarkers are validated on blood samples from patients, recruited at the IRE/IFO hospital in Rome and the University Hospital in Alexandria, before and three hours after radiation therapy. During the NATO project some very interesting research topics, not covered by the established budget, have emerged. Therefore, in the frame of the Italy – Egypt Joint Science and Technology Cooperation a new project started aimed to:- Characterization of the circulating exosomes to verify their use as radiation biomarker and their role in modulating the effect of further irradiation;- Deepening of the inflammatory response by amplifying the analysis of cytokines and other inflammatory circulating factors;- Strengthening the integration of skills and scientific competences between Italy and Egypt by increasing the young scientists interchanges, training stages, inter-laboratory comparison, e-training and web conferences for what concerns biomarkers and clinical dosimetric aspects;- Adding at the HIPH (ET) a third time point, 24 h after radio-treatment for better follow the biomarkers’ kinetic.